Introduction: Infectious endocarditis (IE) is a severe pathology. Its epidemiological, clinical and evolutive profi le varies a lot depending if it is in the context of a developed country or developing country. In our context, very little data exists on the subject.

We present a patient with a large right atrial (RA) thrombus complicated by paroxysmal complete atrioventricular (AV) block requiring urgent surgery. This is a rare complication of RA thrombi with the potential pathogenesis being direct mechanical insult on the AV node by the thrombus. Surgical thrombectomy led to complete resolution.

Background: Randomized trials have shown that oral direct factor Xa inhibitors (ODIXa) offer potential advantages over vitamin K antagonists (VKAs). It is however unclear whether the magnitude of their benefi t is similar at the current recommended doses. Objective: We assessed bleeding risks and total mortality associated with ODIXa therapy compared to VKAs among patients with non-valvular atrial fi brillation or acute venous thromboembolic disease. Methods: Medline, Embase and Cochrane library databases were searched to identify all randomized controlled trials comparing ODIXa to VKAs. The main outcomes were major bleeding, major and clinically relevant non-major (CRNM) bleeding, intracranial haemorrhage, gastrointestinal bleeding, total bleeding events and overall mortality. Pooled odds ratios were calculated with random effect model.Metaregression was performed.

The main cause of death in the world continues to be cardiovascular disease, which affects annually over 900,000 people and in the entire word approximately 50% of the people suffering myocardial infarction (MI) die within 5 years. MI causes a number of cardiac pathologies like hypertension, blocked coronary arteries and valvular heart diseases resulting ischemic cardiac injury. In the last years, cardiac tissue engineering has made considerable progress, because this progress have been made towards developing injectable hydrogels for the purpose of cardiac repair and/or regeneration. This study aims to provide an updated survey of the major progress in the fl ied of injectable cardiac tissue engineering, including biomaterials (natural, synthetic or hybrid hydrogels), their advantages or disadvantages and the main seeding cell sources. Also, this review focuses on the progress made in the field of hydrogels for cardiac tissue repair and/or regeneration for MI over the last years.